This is the profile for the plant – Cistus monspeliensis / White Rockrose / Ċistu abjad. Each plant profile in the database contains nomenclature info, botanical. Position: Require a sheltered position in full sun and light well drained soil. Pruning: No need to prune. Cistus monspeliensis is native to the Mediterranean area and the Canary Islands. It makes a tough drought tolerant evergreen shrub some cm tall by
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Energy cistuss is a very important process to improve and maintain health from the point of view of physiology. It is well known that the mospeliensis ATP production is contributed to energy metabolism in cells. Cistus monspeliensis is widely used as tea, spices, and medical herb; however, it has not been focusing on the activation of energy metabolism. In this study, C. In addition, the promotion of metabolites of glycolysis and TCA cycle was induced by C.
These results suggest that C.
Plants Profile for Cistus monspeliensis (Montpelier cistus)
A lot of natural herbs distributed around the Mediterranean Sea have been traditionally used by local people [ 1 ]. Most of the studies on plants to grow for Mediterranean climate have been investigated mainly in tolerance for the drying and relationship with environmental stress. However, the physiological function of natural herb is still poorly understood though many species grow allover the place. In an area of North Africa, the several species of natural herb were employed in traditional medicine as active against Helicobacter pylorioxidative stress, hypertension, and hypoglycaemic [ 2 — 4 ].
Cistus monspeliensis is a perennial plant which in widely distributed from South Europe to North Africa. The genus Cistus is popular on tea and spice but not utilized for the antiaging effects. In the small intestine, goblet cells secrete mucus that forms a coating over the epithelial layer.
The main function of epithelial layer includes absorption of food compounds [ 6 ]. The ingested capsaicin was carried into the intestinal epithelium, which is in contact with a high concentration of food ingredients [ 78 ]. Considering the relevance of the food components and the effects of the oral route for human exposure, we have investigated the effect of capsaicin on the energy metabolism of intestine, by using Caco-2 cell line, a well-known in vitro model of intestinal epithelium [ 6 ].
The intracellular ATP accumulation is important for optimal integrity of the mucosa and has been suggested to play a specific role in the regulation of absorption and barrier functions [ 910 ]. From these reports, it was supposed that the intracellular ATP accumulation contributes to the homeostasis of Caco-2 cells, because the regulation of absorption and barrier functions are necessary for Caco-2 cells differentiation [ 11 ].
In this study, the energy metabolism underlying the effect of C. This is the first report that the extract of C. The extract water was filtered and sterilized using 0. The antioxidant effect of plants was determined by DPPH 1,1-diphenylpicrylhydrazyl assay performed. At the end of the reaction, a melting curve analysis was carried out to check for the presence of primer dimers. Cells were scraped in 1. Hrinse buffer: Hsample injection: ESI negative, MS capillary voltage: H [ 12 ].
Caco-2 cells were plated in well plates at 1.
The viability of cells was determined icstus MTT 3- 4,5-dimethylthiazolyl -2,5-diphenyltetrazolium bromide assay. Briefly, Caco-2 cells were konspeliensis in well plates at 1. DPPH radical is well known as a stable organic free radical which has been used for estimation of the antioxidant capacity.
DPPH radical is changed to nonradical to react antioxidants. We determined the antioxidation of 23 plants grow around the Mediterranean Sea. Effect of antioxidant of 23 plants extracts. The radical 2,2-diphenylpicryhydrazyl DPPH was used for measuring the antioxidants. The hot water extract and the ethanol extract were diluted to 10 or times monspelienzis each solution. The values of antioxidant were calculated by the following formula: To investigate the effect of C.
In this experiment, we used the primers of triosephosphate isomerase TPIphosphoglycerate mutase PGMand ATP synthase that have a deep relationship with intracellular ATP production and relatively higher expression in Caco-2 cells. Especially, to treat 0. PGM is an enzyme that catalyzes the internal transfer of a phosphate group from C-3 to C-2 which results in the conversion of 3-phosphoglycerate to 2-phosphoglycerate through a 2, 3-bisphosphoglycerate intermediate.
TPI is an enzyme that catalyzes the reversible interconversion of the triose phosphate isomers, dihydroxyacetone phosphate, and D-glyceraldehyde 3-phosphate. TPI plays an important role in glycolysis and is essential for efficient energy production. ATP synthase is an important enzyme that creates energy for the cell to use through the synthesis of ATP in mitochondria. Also, ATP synthase, electron transport chain enzyme, was increased. As a result of the metabolomics analysis, C.
Glycolysis is a pathway of ATP production in anaerobic. In this result, three metabolites on rate-limiting step in glycolysis glucose 6-phosphate, fructose 1,6-diphosphate, and pyruvic acid were increased by C. Especially, pyruvic acid was the most increased in glycolytic metabolites.
Antiaging on promoting energy metabolism is expected to promote function of glycolytic and electron transport chain enzymes that are mlnspeliensis of ATP production. Quantified levels of metabolites involved in glycolysis pathway were determined. Caco-2 cells were treated with 0.
The ratio of quantified levels of metabolites was calculated by Caco-2 cells treated or nontreated with C.
In the results of real-time PCR and metabolomics, C. We determined ATP production of C. As a result, we considered that C. We determined cell proliferation on Caco-2 using MTT assay. From ciwtus result of MTT assay, 0.
Species name :
As a result, we considered that 0. In this role, ATP transports chemical energy within cells for metabolism. TPI enzyme is essential for energy production, allowing two molecules mospeliensis glyceraldehyde 3-phosphate to be produced for every glucose molecule, thereby doubling the energy yield. PGM enzyme catalyzes 1,3-bisphosphoglycerate and plays an important role downstream of glycolysis.
The activity of TPI and PGM was not influenced by age or caloric restriction [ 16 ], while the other glycolytic enzymes were influenced. Furthermore, the activity and expression of these two enzymes, however, are decreased by oxidation and disorders Alzheimer’s disease, hemolytic anemia, erythrocyte destruction, etc.
These observations indicate that the expression and activity of these glycolytic enzymes were upregulated in minspeliensis to specific signals, such as C. Furthermore, ATP synthase contains a rotary motor involved in biological energy conversion.
However, these enzymes have contribution toward not only ATP production but also regulation of cellular function. Its deficiency has been known to cause a severe multisystemic disease with autosomal recessive inheritance cistuss 19 ] and neurodegeneration [ 20 ]. The methylglyoxal induces oxidative damage to proteins and DNA and accumulation of advanced glycation end products AGEswhich leads to structural degeneration and functional decline of brain cells [ 21 ].
Monoubiquitination of phosphoglycerate mutase, as well as formation of a noncovalent complex containing ubiquitin mondpeliensis phosphoglycerate mutase, increased in colorectal cancer, which may suggest a potential pathophysiological event [ 23 ]. A monxpeliensis level of phosphoglycerate mutase isoenzymes was reported in breast carcinoma [ 24 ] indicating its differential expression.
Active regulation of the mitochondrial ATP-synthase complex V in response to the cellular energy demand has been demonstrated in several monsleliensis like rat, dog, and humans and different types of tissue like heart muscle, skeletal muscle, fibroblasts, and brain. Regulation of the ATP-synthase seems to be a central physiological phenomenon which is presumably present in many other species monspeliensiz other organs.
As energy supply via the mitochondrial ATP-synthase plays such a vital role in almost every cell of the body, more diseases will probably be identified where primary or secondary abnormalities of this enzyme occur ccistus 25 ]. In addition, one of the causes of aging, free radical, is focused on oxidative cytotoxic. Especially, oxidative cytotoxic in mitochondrion is related to aging [ 26 ].
Mitochondrion that is important as metabolism organ of ATP production caused impairment accompanied effect of aging and ROS. Also, it is known that function of SOD decreased [ 27 ].
From this paper, the effect of enhancement component on ATP production can make use of antiaging effector as well as functional foods for antiaging.
Our research showed that C. From these results, we suggest that C. It is known that species of Cistus contain quercetin, kaempferol, aesculin, myricetin, and flavanols [ 28 ]. For example, quercetin has antioxidation and has a function to improve memory impairment that accompany Alzheimer’s disease [ 29 ]. Moreover, it is known that an aging is caused for decline of intestinal absorption [ 3031 ].
We expect that C. On the other hand, 0. From these results, we considered that ATP was consumed for cell proliferation in 0.
It was reported that the ATP accumulation was contributed to the proliferation and homeostasis on Caco-2 cells [ 10 ]. We considered that isolation of active component from C. Our findings indicate that C. monspeliensiz
Monsprliensis addition, we show that C. From these results, C. Further studies are in progress to elucidate the effect of C. National Center for Biotechnology InformationU. Journal List J Biomed Biotechnol v. Published online Mar Author information Article notes Copyright and License information Disclaimer. This is an open access article distributed under the Creative Commons Attribution License, konspeliensis permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.